杩??ワ?瀛︽?″?ㄧ?╃???瀛﹂?㈡?逛?涓???????浠ョ?涓?浣?????span>Nature??涓?????Mucosal Immunology锛?褰卞????瀛?7.4锛??诲?澶х被涓??猴?锛??ㄧ嚎??琛ㄩ?涓?span>??ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism.??( ASC??NLRP3??杩?????灏?浣???渚?璧?????寰?缁存???煎?搁??澶╃?跺????ǔ?????哄??span>)??瀛︽???????
????灏?浣?锛?Inflammasome锛????涓诲ぉ?跺?????绛?涓???瑕??????藉???浣?锛?????杩?娲诲??caspase-1璇卞???????搴?淇??ゅ?涓绘??????浣???????浣????ㄨ?虹???剧?????ц?虹??涓?????灏?浣??ュご????span>ASC????浣???瀛?NLRP3????杩?caspase-1??渚?璧?????寰?淇??ゅ?涓绘???虹???剧????????????绌惰?涓?姝ュ????span>ASC??杩?STAT6-SPDEF淇″?烽??璺???т?娓哥??瀹夸富?插尽??瀛?TFF2??Intelectin-1绛?淇??ゅ?涓绘????????璇ョ??绌堕????浜?ASC??杩?????灏?浣???渚?璧?????寰??ㄥ?煎?搁??绮???澶╃?跺????腑??浣??ㄦ?哄?讹???ず浜?ASC浣?涓虹????灏?浣??ュご???戒?澶????板???斤?涓?span>ASC?????界??绌舵??渚??扮????璺???
Mucosal Immunology琚??涓烘???ㄧ??绮????????????濞????介????蹇?涔?涓?锛?涔???タ??澶у??ㄧ?╃???瀛﹂?㈤?娆′?涓虹?涓?瀹?????浣??ㄨ?????涓???琛ㄥ?????????ユ????娉藉ぇ瀛︼?Kanazawa University锛?涓洪??璁??????浣?锛?Dr. Kohsuke Tsuchiya涓鸿?璁烘??????璁???????逛?涓???????涓??ユ????娉藉ぇ瀛︿???浜??挎????濂界??绉?????浣?锛?璇ョ??绌跺??颁??藉????圭????璁″?????藉????剁?瀛﹀?洪?????ユ?????ㄧ??绛?椤圭????璧??┿??
????锛??ㄧ?╃???瀛﹂??span>2019骞村??缁?瀛︾???绌舵?瑰??骞剁?寤轰?11涓???????板?㈤?????逛?涓?????????江杩?涔??????靛ご?????ㄧ?╃????寰????╀????????板?㈤????????绌堕?骞诧??挎???村??浜???????????涓???????归?㈢????绌躲??杩?骞存?ワ???span>Veterinary Microbiology??Infection and Immunity??Innate Immunity绛?SCI浜??哄??浠ヤ???蹇???琛ㄥ???????扮???
?????炬?ワ?https://www.ncbi.nlm.nih.gov/pubmed/31278375
锛??ㄧ?╃???瀛﹂???绋?nbsp; 缂?杈? ?╃? 瀹℃??nbsp; ?ㄧ勘锛?