杩??ワ?瑗垮??澶у?璧?婧?????????绘?涓??╃?ㄥ?ㄥ?介???瑰?楠?瀹や唬?归?舵?????㈤?????颁?璋??у??界???板?哄??OSER1锛?骞跺?ㄥ?????绾胯????????绛?澶??╃?涓???绌舵??ず浜??堕??杩??????轰?瀵规哀??搴?婵????插尽????寤剁?琛拌????寤堕?垮??界??淇?瀹??ф?哄?讹?灞?绀轰?OSER1浣?涓哄??板?ュ悍琛拌????寤堕?垮??界???抽????ч?舵??????瑕?????????绌舵????浜?杩???/font>?ㄥ?介???ュ????????????/font>??璁???锛?Nature Communications锛??ㄧ嚎??琛?/font>锛????板?浣?骞挎??虫敞锛?浜烘??ユ?ャ???板??绀俱???????ユ?ャ??绉????ユ?ャ????姘??ユ?ャ??涓??界?瀛︽?ャ????搴??ユ?ョ?濯?浣?瀵规????杩?琛?浜??ラ????
?板??绀炬?ラ???ㄦ??濡?涓?锛?
杩??ワ?瑗垮??澶у?璧?婧?????????绘?涓??╃?ㄥ?ㄥ?介???瑰?楠?瀹ゆ????浠ｆ?归?跺?㈤???????藉?涓?瀹剁??绌跺???拌??у??界???板?哄??OSER1锛?骞跺?ㄥ?????绾胯????????绛?澶??╃?涓???绌舵??ず浜??朵??ㄦ?哄?躲??浣?涓洪?垮??哄??FOXO锛???澶存?????/font>O锛????跺?哄??锛?OSER1瀵瑰??界??褰卞??寰??颁汉绫诲??璇?????绌剁?????????
???缁?锛???澶存?????/font>O??????宸茬‘瀹???灏??板??涓?汉绫婚?垮??哄??涔?涓???瀹???杩?璋???涓?琛拌???稿?崇????寰?褰卞??瀵垮?斤?浣?????锛?浠?瀵艰?浜?浣??ㄧ???剁?瑰?ㄥ?澶х?搴︿?浠??舵???ャ????绌惰〃??锛???澶存?????/font>O?ㄤ???妯″??ㄧ?╅?寸??浜?绾х????锋??杈?楂?淇?瀹??э?杩?涓哄?╃?ㄥ???绛?绛???瀵垮?借??ч?跺?哄????渚?浜?渚?????
??绌跺?㈤???╃?ㄧ嚎?????骞叉?骞冲?帮?瀵瑰???涓???澶存?????/font>O??42涓???ㄧ?存?ラ?跺?哄???ㄧ嚎??腑???寸郴??婧??哄??杩?琛?骞叉?瀹?楠?锛????板?朵腑7涓??哄??琛ㄨ揪涓?璋???绾胯????芥?捐??缂╃???3涓??哄??琛ㄨ揪涓?璋???绾胯????芥?捐??寤堕?裤???朵腑锛?绾胯??腑OSER1??婧??哄??琛ㄨ揪??浣???锛?瀵垮?界缉???搴︽??澶с??
????浠??绾胯????瀹惰????????????椹?奔????娲茬???俱??灏?榧?????娌崇?翠?浜虹被杩?琛?姣?杈?????锛????板?跺?哄??缁?涓???瀛???/font>OSER1???寸郴??婧??哄??????璁烘??绗??浣?????瑗垮??澶у?璧?婧?????????绘?涓??╃?ㄥ?ㄥ?介???瑰?楠?瀹ゅ??????瀹?姹?娉??缁?锛?杩?涓?姝ョ??绌舵?剧ず锛??ㄥ?????绾胯????????涓????楂?OSER1琛ㄨ揪??锛?3涓??╃???瀵垮?藉???捐??寤堕?裤??
涓轰?????OSER1璋????垮???浣??ㄦ?哄?讹???绌跺?㈤???ㄥ?????绾胯????????涓??琛?浜?涓?绯诲??????瀛????╁?瀹?楠?????绌剁????卞??琛ㄦ??锛?OSER1????澶存?????/font>O???存?ラ?跺?哄??锛?OSER1?藉???搴?杩?姘у??姘㈣?瀵肩??姘у??搴?婵?锛?骞堕??杩??????轰?姘у??搴?婵??插尽?????ュ欢?垮??界??浣??ㄣ??
??浜虹被??璇?????绌剁???涔?????OSER1褰卞??浜虹被瀵垮?界??瑙??广????瀹?姹?娉??缁?锛??㈤????绌跺???帮?90宀?浠ヤ????垮???浜轰?骞磋交瀵圭?х??告?锛?妫?娴???/font>OSER1?哄??涓????/font>49涓?父瑙????歌?烽?稿??寮?锛??朵腑7涓???垮??捐???稿?炽??
璇ョ??绌舵????杩??ュ?ㄥ?介??瀛︽???????????堕??璁????ㄧ嚎??琛ㄣ??璁烘??璇?瀹′?瀹惰〃绀猴???璇ョ??绌跺???颁???澶存?????/font>O??涓?涓??扮???跺?哄??锛?涓????╁????界??绌跺己??璇????跺?锋???╃??村?遍???э?杩?灏?淇?杩?瀵瑰??澶存?????/font>O璋??у??介??寰???杩?涓?姝ョ??绌躲????
?╁???璇伙?
https://www.nature.com/articles/s41467-024-51542-z