杩??ワ?瑗垮??澶у???娌夸氦??瀛︾???绌堕?㈢???╁???绌朵腑蹇?绋?????????璇鹃?缁??ㄥ?介???ュ????????缇??界?瀛﹂?㈤?㈠????锛?PNAS锛??ㄧ嚎??琛ㄤ?棰?涓衡??杞????瀛?Schlank??杩?浠?瀵煎???歌?轰腑H3K27涔??板?????插?哄??淇?グ??杞???璋??ф????????????/font>??锛?Schlank orchestrates insect developmental transition by switching H3K27 acetylation to trimethylation in the prothoracic gland锛?????绌惰?????璇ョ??绌朵互瀹惰????????涓烘ā寮?锛????拌浆褰???瀛?Schlank浠?瀵煎辜??????舵????歌?虹???涓?????缁?????3K27涔??板??淇?グ锛?H3K27ac锛???涓??插?哄??淇?グ锛?H3K27me3锛?杞???锛?杩??????朵?骞兼?绱?淇″?疯浆瀵煎??瀛?Hairy??杞??锛???缁?淇?杩??????绱?????涓????????层??璇ョ??绌剁郴缁?瑙ｆ??浜?H3K27淇?グ妯″???????璋??ф???????茶浆????琛ㄨ???浼??哄?躲??
?????????夸????蹭富瑕?渚?璧?浜?涓ゅぇ????娉?婵?绱??充?骞兼?绱?锛?juvenile hormone, JH锛????????绱?锛?ecdysone锛???????璋??с???ㄥ辜???涓???????╂??锛??戒晶浣?澶ч????????娉?淇?骞兼?绱?锛??朵??ㄥ?ㄤ?缁存??骞艰?????裤??浣?????ㄥ辜???涓??????????锛????歌?猴?prothoracic gland, PG锛?澶ч????????娉??????绱?锛?浠??????ㄥ辜??????????骞艰?????圭?????????层??淇?骞兼?绱?涓??????绱??ㄦ???????夸????蹭腑??????浣??ㄥ???跺??瀛??哄?舵??涓轰?绉?瀛﹀?浠?箍娉??虫敞???︾?广??缁????芥?????哥???╂???茶川缁??????烘???????浠讹?涓昏?????2A??H2B??H3??H4绛???缁????藉?ㄧ?瑰??′欢涓??????插?哄????涔??板????娉?绱???绛?缈昏???淇?グ锛?浠?????杩?褰卞???瑰????茶川?哄????缁??????????ф?ユ?娲绘?????堕?跺?哄????杞??锛?瀹??板??瑰????╁?杩?绋???琛ㄨ???浼?璋??с??缁?????3绗?7浣?璧?姘ㄩ?稿??????涔??板??锛?H3K27ac锛????插?哄??锛?H3K27me3锛?涓ょ??镐???????淇?グ锛?????浣挎???茶川?炬?ｈ??婵?娲诲?哄??杞??锛?????瀵艰?存???茶川娴?缂╄??娌?榛??哄????绋?????????璇鹃?缁?涔???????绌跺???帮?淇?骞兼?绱?淇″?疯浆瀵煎??瀛?Hairy?ㄦ????辜??????╂???????歌?轰腑楂?琛ㄨ揪锛????惰?????绱??????????????诧??ㄥ辜??????????????歌?轰腑锛?Hairy?哄??????H3K27me3淇?グ??杞??娌?榛?锛?浠???瑙ｉ?や?骞兼?绱?瀵硅?????绱??????????????茬?????朵????琛ㄦ??H3K27me3淇?グ瀵硅?????绱??????????????插???ヤ?姝ｈ??т????PNAS, 2021锛????惰??锛????????????蹭互??涓ょ?????娉?婵?绱???浜?浣????︽???H3K27ac淇?グ???朵?H3K27me3??????浣??ㄥ?涓?娓?妤???
????绌跺???帮??ㄥ???????????骞艰??????舵?锛????歌?轰腑?讳???H3K27ac淇?グ姘村钩?????茶?绋???娓???浣?锛??ㄧ????藉?讳??板????pd3?????跺??TSA澶???瀹惰??骞艰?????ㄦ???????歌?轰腑?瑰??查??Rpd3锛?浣垮???歌?轰腑H3K27ac淇?グ姘村钩??楂?锛?缁???瀵艰?磋?????绱??????????????插???汇??
涓?浠?濡?姝わ?????绌惰?????/font>TSA澶?????Rpd3?查???捐????浣?浜????歌?轰腑?讳???浠ュ??Hairy?哄??涓???H3K27me3淇?グ??姘村钩锛?骞朵?璋?Hairy琛ㄨ揪锛??查??Hairy?芥?芥??Rpd3?查????瀵艰?寸??寮?甯歌〃????杩?浜?璇???〃??锛?瀹惰????????骞艰????????????歌?轰腑Hairy?哄??涓?????H3K27ac淇?グ??H3K27me3淇?グ??杞???锛?浠???浣?airy杞??涓?璋?骞朵?杩??????绱?????涓????????层??
????绌惰?涓?姝ユ繁?ヨВ??浜?骞艰????????歌?轰腑H3K27ac??H3K27me3淇?グ杞???骞惰???????airy杞????绮剧?璋??ф?哄?躲???翠??哄??杞??寰?寰???瑕??瑰?杞????瀛???涓?锛?????绌跺????????浜?瀹惰??骞艰??????╂?????????????歌?虹??杞??缁?锛?绛????峰??ㄥ????琛ㄨ揪涓?璋???杞????瀛???缁ц???ㄦ???????歌?轰腑瀵硅?浜?瀹惰??杞????瀛?????????婧?浣?杩?琛??查??锛???杩????????歌?轰腑?讳???浠ュ??Hairy?哄??涓?H3K27ac??H3K27me3涓ょ?淇?グ??姘村钩????锛???缁?纭??杞????瀛?Schlank浠?瀵间????歌?轰腑Hairy?哄??涓?H3K27ac??H3K27me3??杞?????
????锛?????绌跺?Schlank???蜂?浣??ㄦ?瑰?杩?琛?浜?璇︾??㈢┒锛?涓昏????板??????ㄥ???歌?轰腑?瑰??查??Schlank?????惰?????绱?????骞堕?荤?骞艰?????圭??杞???锛?杩?琛ㄨ揪Schlank??淇?杩??????绱?????骞惰?瀵煎???规????锛?Schlank??杩??跺??婧?寮???缁??????存?ョ???Hairy?哄???????ㄥ?锛?骞堕??杩????戒?浣?灏?H3K27???讳??板????pd3浠ュ???插?哄????RC2???稿?浜???u(z)12??????airy?哄?????ㄥ??猴?浠???瀹???airy?哄??涓?H3K27ac??H3K27me3??杞???锛??存?ユ????airy杞??锛?Schlank瀵?3K27涔??板?????插?哄??杞?????璋??т??ㄨ?淇?骞兼?绱????讹?浣????拌?????绱???姝ｅ??棣?璋??с??
缁间???杩帮?????绌惰?瀹?杞????瀛?Schlank??杩?浠?瀵煎辜??????舵????歌?轰腑缁?????3K27涔??板??淇?グ??涓??插?哄??淇?グ??杞???锛?浠?????杩????朵?骞兼?绱?淇″?疯浆瀵煎??瀛?Hairy??杞???ヨВ?や?骞兼?绱?瀵硅?????绱??????????朵??????缁?淇?杩??????绱??????????????层??杩?浜???瑕????扮郴缁?????浜?缁?????3K27淇?グ??涓?璋???????????娉?婵?绱?????浣??ㄥ苟褰卞?????????????茬??琛ㄨ???浼??哄?讹?涓板?瀹???浜????????茶浆??????瀛?璋??х?缁???
??澹?????绌剁??琚????翠负璁烘??绗??浣???锛?绋????????????辨??????????涓鸿?????璁????锛?澶?搴???????瀵硅?椤圭??绌剁?浜???瑕???瀵笺??????绌跺??板?藉????剁?瀛﹀?洪??????搴?甯????剁?瀛﹀?洪??绛?椤圭????┿??
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https://www.pnas.org/doi/10.1073/pnas.2401861121